Drug interactions
Isocarboxazid + Olodaterol inhaled
Severity: Moderate
Isocarboxazid and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labeling for long-acting beta2 agonists advises extra caution with MAO inhibitors because cardiovascular effects of the beta agonist may be potentiated. This can manifest as tachycardia, palpitations, blood pressure changes or QTc prolongation and arrhythmia.
What this interaction means in plain words
Isocarboxazid and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition can potentiate sympathomimetic cardiovascular effects, adding to beta2 agonist-induced tachycardia and QT effects.
What to do
Monitor heart rate, blood pressure and symptoms of arrhythmia, and consider an ECG in patients with cardiac risk factors. Use the lowest effective olodaterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Isocarboxazid and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labeling for long-acting beta2 agonists advises extra caution with MAO inhibitors because cardiovascular effects of the beta agonist may be potentiated. This can manifest as tachycardia, palpitations, blood pressure changes or QTc prolongation and arrhythmia.
How serious is the interaction between Isocarboxazid and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and symptoms of arrhythmia, and consider an ECG in patients with cardiac risk factors. Use the lowest effective olodaterol dose.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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