Drug interactions
Isocarboxazid + Papaveretum
Severity: Major
Isocarboxazid and Papaveretum: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains morphine and other opium alkaloids. Together with an MAOI it can produce serotonin toxicity or severe opioid effects including respiratory depression, hypotension and coma.
What this interaction means in plain words
Isocarboxazid and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Probable additive CNS depression and serotonergic effects; mechanism not fully established.
What to do
Avoid the combination during MAOI therapy and for 14 days after discontinuation; use a non-opioid analgesic where possible. If unavoidable, give small titrated doses with close cardiorespiratory monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Papaveretum?
MediHelp rates the interaction as major. Isocarboxazid and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains morphine and other opium alkaloids. Together with an MAOI it can produce serotonin toxicity or severe opioid effects including respiratory depression, hypotension and coma.
How serious is the interaction between Isocarboxazid and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination during MAOI therapy and for 14 days after discontinuation; use a non-opioid analgesic where possible. If unavoidable, give small titrated doses with close cardiorespiratory monitoring.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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