Drug interactions
Isocarboxazid + Remimazolam
Severity: Major
Isocarboxazid and Remimazolam: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and combined use may cause profound sedation, respiratory depression and hypotension.
What this interaction means in plain words
Isocarboxazid and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isocarboxazid belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Titrate remimazolam carefully to effect with continuous monitoring of oxygen saturation and vital signs. Have airway support available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Byfavo 20 mg powder for solution for injection - SmPC sections 4.3/4.5 (class statement: sedative antidepressants; "sedative antidepressants") — electronic medicines compendium (UK SmPC)
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Isocarboxazid with Remimazolam?
MediHelp rates the interaction as major. Isocarboxazid and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the CNS, and combined use may cause profound sedation, respiratory depression and hypotension.
How serious is the interaction between Isocarboxazid and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully to effect with continuous monitoring of oxygen saturation and vital signs. Have airway support available.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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