Drug interactions
Isocarboxazid + Same
Severity: Major
Isocarboxazid and Same: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine may raise serotonergic activity, and combining it with an MAOI could lead to serotonin syndrome. Reported effects include agitation, tremor, sweating and hyperthermia.
What this interaction means in plain words
Isocarboxazid and Same can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effect: SAMe may increase serotonin synthesis while the MAOI blocks its breakdown.
What to do
Avoid concurrent use; advise patients on MAOIs not to take SAMe supplements. Stop SAMe and treat supportively if serotonin toxicity occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Same?
MediHelp rates the interaction as major. Isocarboxazid and Same can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. S-adenosylmethionine may raise serotonergic activity, and combining it with an MAOI could lead to serotonin syndrome. Reported effects include agitation, tremor, sweating and hyperthermia.
How serious is the interaction between Isocarboxazid and Same?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; advise patients on MAOIs not to take SAMe supplements. Stop SAMe and treat supportively if serotonin toxicity occurs.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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