Drug interactions
Isocarboxazid + Selegiline transdermal
Severity: Contraindicated
Isocarboxazid and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two MAO inhibitors together increase the risk of hypertensive crisis and serotonin syndrome. Transdermal selegiline at antidepressant doses inhibits both MAO-A and MAO-B.
What this interaction means in plain words
Isocarboxazid and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive irreversible inhibition of monoamine oxidase.
What to do
Do not co-administer; allow at least 14 days between stopping one MAOI and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Two MAO inhibitors together increase the risk of hypertensive crisis and serotonin syndrome. Transdermal selegiline at antidepressant doses inhibits both MAO-A and MAO-B.
How serious is the interaction between Isocarboxazid and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days between stopping one MAOI and starting the other.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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