Drug interactions
Isocarboxazid + Serdexmethylphenidate / dexmethylphenidate
Severity: Contraindicated
Isocarboxazid and Serdexmethylphenidate / dexmethylphenidate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This methylphenidate-type stimulant combined with an MAOI can precipitate hypertensive crisis. Severe headache, cardiac arrhythmia and stroke may result.
What this interaction means in plain words
Isocarboxazid and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Stimulant-induced catecholamine release and reuptake blockade combined with inhibited catecholamine breakdown.
What to do
Do not use during or within 14 days of MAOI treatment; select a non-stimulant option.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This methylphenidate-type stimulant combined with an MAOI can precipitate hypertensive crisis. Severe headache, cardiac arrhythmia and stroke may result.
How serious is the interaction between Isocarboxazid and Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during or within 14 days of MAOI treatment; select a non-stimulant option.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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