Drug interactions
Isocarboxazid + Sufentanil sl
Severity: Major
Isocarboxazid and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil with an MAOI may cause serotonin syndrome or opioid toxicity including respiratory depression and coma. The risk persists for up to 14 days after stopping the MAOI.
What this interaction means in plain words
Isocarboxazid and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects and potentiated CNS and respiratory depression.
What to do
Do not use sufentanil SL within 14 days of an MAOI; select a non-opioid or alternative analgesic. If urgent, use small test doses and monitor blood pressure, mental status and respiration frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Sufentanil sl?
MediHelp rates the interaction as major. Isocarboxazid and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil with an MAOI may cause serotonin syndrome or opioid toxicity including respiratory depression and coma. The risk persists for up to 14 days after stopping the MAOI.
How serious is the interaction between Isocarboxazid and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use sufentanil SL within 14 days of an MAOI; select a non-opioid or alternative analgesic. If urgent, use small test doses and monitor blood pressure, mental status and respiration frequently.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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