Drug interactions
Isocarboxazid + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Isocarboxazid and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta2-agonist, and MAOIs can potentiate its cardiovascular effects. This may result in tachycardia, palpitations, hypertension and arrhythmias.
What this interaction means in plain words
Isocarboxazid and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition increases adrenergic neurotransmitter availability, amplifying beta-agonist cardiovascular stimulation.
What to do
If both are needed, monitor heart rate, blood pressure and ECG symptoms, particularly at initiation and within 2 weeks of stopping the MAOI. Consider an alternative bronchodilator if cardiovascular effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Isocarboxazid and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta2-agonist, and MAOIs can potentiate its cardiovascular effects. This may result in tachycardia, palpitations, hypertension and arrhythmias.
How serious is the interaction between Isocarboxazid and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, monitor heart rate, blood pressure and ECG symptoms, particularly at initiation and within 2 weeks of stopping the MAOI. Consider an alternative bronchodilator if cardiovascular effects emerge.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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