Drug interactions
Isocarboxazid + Yohimbine
Severity: Contraindicated
Isocarboxazid and Yohimbine: contraindicated interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine increases noradrenergic outflow and with an MAOI may lead to hypertension, anxiety and tachycardia. Severe hypertensive reactions are possible.
What this interaction means in plain words
Isocarboxazid and Yohimbine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Alpha-2 antagonism increases noradrenaline release, which is potentiated by reduced MAO-mediated breakdown.
What to do
Avoid the combination and use alternative therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Yohimbine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Yohimbine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Yohimbine increases noradrenergic outflow and with an MAOI may lead to hypertension, anxiety and tachycardia. Severe hypertensive reactions are possible.
How serious is the interaction between Isocarboxazid and Yohimbine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternative therapy.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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