Drug interactions
Isoflurane + Metoclopramide intranasal
Severity: Moderate
Isoflurane and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has central dopamine-blocking and sedative effects that may add to the CNS depression of a general anesthetic. Reduced anesthetic requirements and increased sedation may occur, and extrapyramidal reactions or hypotension may complicate the perioperative course.
What this interaction means in plain words
Isoflurane and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression; the exact mechanism of any further interaction is not well established.
What to do
Titrate isoflurane concentration to clinical effect and anesthetic depth monitoring, and watch for prolonged sedation or extrapyramidal symptoms after surgery. Consider holding elective metoclopramide dosing around the procedure if an alternative antiemetic is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoflurane and Metoclopramide intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Isoflurane and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide has central dopamine-blocking and sedative effects that may add to the CNS depression of a general anesthetic. Reduced anesthetic requirements and increased sedation may occur, and extrapyramidal reactions or hypotension may complicate the perioperative course.
How serious is the interaction between Isoflurane and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate isoflurane concentration to clinical effect and anesthetic depth monitoring, and watch for prolonged sedation or extrapyramidal symptoms after surgery. Consider holding elective metoclopramide dosing around the procedure if an alternative antiemetic is suitable.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
