Drug interactions
Isoflurane + Yohimbine
Severity: Moderate
Isoflurane and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine increases sympathetic outflow and can cause hypertension and tachycardia. Isoflurane sensitizes the myocardium to catecholamines, so the combination may provoke arrhythmias and unstable blood pressure, although the evidence is limited.
What this interaction means in plain words
Isoflurane and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Yohimbine blocks alpha-2 receptors and raises catecholamine release, and volatile anesthetics increase myocardial sensitivity to catecholamines; the interaction is largely theoretical.
What to do
Stop yohimbine before elective anesthesia where feasible. Monitor blood pressure and ECG continuously and treat hypertension or arrhythmias promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Yohimbine?
MediHelp rates the interaction as moderate. Isoflurane and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine increases sympathetic outflow and can cause hypertension and tachycardia. Isoflurane sensitizes the myocardium to catecholamines, so the combination may provoke arrhythmias and unstable blood pressure, although the evidence is limited.
How serious is the interaction between Isoflurane and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop yohimbine before elective anesthesia where feasible. Monitor blood pressure and ECG continuously and treat hypertension or arrhythmias promptly.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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