Drug interactions
Isoniazid + Istradefylline
Severity: Moderate
Isoniazid and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline is metabolized by CYP3A4 and CYP1A1, and its exposure increases with strong CYP3A4 inhibitors, which may worsen dyskinesia and other adverse effects. Isoniazid is a weaker inhibitor, so the effect is probably smaller.
What this interaction means in plain words
Isoniazid and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Istradefylline belongs to Central Nervous System.
Why it happens
Isoniazid inhibits CYP3A4, decreasing the clearance of istradefylline.
What to do
Monitor for dyskinesia, hallucinations and dizziness. Keep istradefylline at or below 20 mg daily during isoniazid therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoniazid and Istradefylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Istradefylline
Frequently asked questions
Can I take Isoniazid with Istradefylline?
MediHelp rates the interaction as moderate. Isoniazid and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline is metabolized by CYP3A4 and CYP1A1, and its exposure increases with strong CYP3A4 inhibitors, which may worsen dyskinesia and other adverse effects. Isoniazid is a weaker inhibitor, so the effect is probably smaller.
How serious is the interaction between Isoniazid and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dyskinesia, hallucinations and dizziness. Keep istradefylline at or below 20 mg daily during isoniazid therapy.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
