Drug interactions
Isoniazid + Lumateperone
Severity: Moderate
Isoniazid and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumateperone is extensively metabolized by CYP3A4, and CYP3A4 inhibitors increase its exposure, which can increase sedation, orthostatic hypotension and other adverse effects. Isoniazid's inhibition is modest, so the increase is likely smaller than with strong inhibitors.
What this interaction means in plain words
Isoniazid and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Lumateperone belongs to Central Nervous System.
Why it happens
Isoniazid inhibits CYP3A4, reducing lumateperone clearance.
What to do
Monitor for sedation, dizziness and orthostatic hypotension. Consider reducing lumateperone to 21 mg daily if a clinically relevant interaction is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Lumateperone
Frequently asked questions
Can I take Isoniazid with Lumateperone?
MediHelp rates the interaction as moderate. Isoniazid and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumateperone is extensively metabolized by CYP3A4, and CYP3A4 inhibitors increase its exposure, which can increase sedation, orthostatic hypotension and other adverse effects. Isoniazid's inhibition is modest, so the increase is likely smaller than with strong inhibitors.
How serious is the interaction between Isoniazid and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and orthostatic hypotension. Consider reducing lumateperone to 21 mg daily if a clinically relevant interaction is suspected.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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