Drug interactions
Isoniazid + Metformin-pioglitazone
Severity: Moderate
Isoniazid and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and may reduce the effectiveness of antidiabetic therapy, leading to hyperglycemia. Glucose may fall again when isoniazid is stopped.
What this interaction means in plain words
Isoniazid and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Isoniazid may impair carbohydrate metabolism; the mechanism is not well established.
What to do
Check blood glucose regularly during isoniazid therapy and adjust the antidiabetic doses as needed. Reassess glucose control after isoniazid is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Isoniazid and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid can impair glucose tolerance and may reduce the effectiveness of antidiabetic therapy, leading to hyperglycemia. Glucose may fall again when isoniazid is stopped.
How serious is the interaction between Isoniazid and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose regularly during isoniazid therapy and adjust the antidiabetic doses as needed. Reassess glucose control after isoniazid is discontinued.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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