Drug interactions
Isoniazid + Metformin-repaglinide
Severity: Moderate
Isoniazid and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and may reduce the efficacy of antidiabetic therapy, leading to loss of glycemic control. It also inhibits CYP3A4 to some degree, which could modestly raise repaglinide exposure, though the clinical effect is not well characterized.
What this interaction means in plain words
Isoniazid and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Metformin-repaglinide belongs to Endocrine.
Why it happens
Isoniazid may cause hyperglycemia through effects on glucose metabolism and can inhibit CYP3A4, reducing repaglinide clearance.
What to do
Monitor blood glucose during isoniazid therapy and adjust antidiabetic doses as needed, watching for hypoglycemia when isoniazid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Isoniazid and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid can impair glucose tolerance and may reduce the efficacy of antidiabetic therapy, leading to loss of glycemic control. It also inhibits CYP3A4 to some degree, which could modestly raise repaglinide exposure, though the clinical effect is not well characterized.
How serious is the interaction between Isoniazid and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during isoniazid therapy and adjust antidiabetic doses as needed, watching for hypoglycemia when isoniazid is stopped.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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