Drug interactions
Isoniazid + Nilotinib
Severity: Major
Isoniazid and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is metabolized by CYP3A4 and prolongs the QT interval. Isoniazid may raise its exposure and increase the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Isoniazid and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoniazid belongs to Anti Bacterial; Nilotinib belongs to Oncology.
Why it happens
Isoniazid inhibits CYP3A4, increasing nilotinib concentrations and QT effects.
What to do
Obtain a baseline ECG and monitor the QTc during therapy, correcting potassium and magnesium. Consider an alternative regimen if the QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoniazid
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Isoniazid with Nilotinib?
MediHelp rates the interaction as major. Isoniazid and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib is metabolized by CYP3A4 and prolongs the QT interval. Isoniazid may raise its exposure and increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Isoniazid and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during therapy, correcting potassium and magnesium. Consider an alternative regimen if the QTc lengthens.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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