Drug interactions
Isoniazid + Palovarotene
Severity: Moderate
Isoniazid and Palovarotene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is a CYP3A substrate, and CYP3A inhibitors can raise its exposure, increasing retinoid-type toxicity such as mucocutaneous effects, bone changes and premature growth plate closure in children. Isoniazid is a relatively weak inhibitor, so the effect is likely modest.
What this interaction means in plain words
Isoniazid and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Palovarotene belongs to Miscellaneous.
Why it happens
Isoniazid inhibits CYP3A4, decreasing the metabolism of palovarotene.
What to do
Monitor for retinoid adverse effects and consider reducing the palovarotene dose if the combination cannot be avoided. Monitor growth in pediatric patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Isoniazid with Palovarotene?
MediHelp rates the interaction as moderate. Isoniazid and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palovarotene is a CYP3A substrate, and CYP3A inhibitors can raise its exposure, increasing retinoid-type toxicity such as mucocutaneous effects, bone changes and premature growth plate closure in children. Isoniazid is a relatively weak inhibitor, so the effect is likely modest.
How serious is the interaction between Isoniazid and Palovarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for retinoid adverse effects and consider reducing the palovarotene dose if the combination cannot be avoided. Monitor growth in pediatric patients.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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