Drug interactions
Isoniazid + Paroxetine
Severity: Moderate
Isoniazid and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid's weak MAO inhibition combined with paroxetine may theoretically increase the risk of serotonin syndrome. Clinical cases are uncommon.
What this interaction means in plain words
Isoniazid and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Paroxetine belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from weak MAO inhibition and serotonin reuptake inhibition.
What to do
Monitor for tremor, agitation, sweating, hyperreflexia and fever. Stop one agent if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Isoniazid with Paroxetine?
MediHelp rates the interaction as moderate. Isoniazid and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid's weak MAO inhibition combined with paroxetine may theoretically increase the risk of serotonin syndrome. Clinical cases are uncommon.
How serious is the interaction between Isoniazid and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, agitation, sweating, hyperreflexia and fever. Stop one agent if serotonin syndrome is suspected.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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