Drug interactions
Isoniazid + Prednisolone
Severity: Minor
Isoniazid and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak, inconsistent inhibitor of some CYP enzymes, and a meaningful rise in prednisolone exposure is not well established. Any increase in corticosteroid effect would be small. Both drugs can affect the liver or glucose handling, so the practical relevance is limited.
What this interaction means in plain words
Isoniazid and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Prednisolone belongs to Endocrine.
Why it happens
Isoniazid may weakly inhibit CYP3A4 metabolism of prednisolone, but the effect is not firmly established.
What to do
No dose change is usually needed; watch for corticosteroid adverse effects such as hyperglycemia during long-term co-therapy. Monitor liver function as part of routine isoniazid care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Prednisolone?
MediHelp rates the interaction as minor. Isoniazid and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak, inconsistent inhibitor of some CYP enzymes, and a meaningful rise in prednisolone exposure is not well established. Any increase in corticosteroid effect would be small. Both drugs can affect the liver or glucose handling, so the practical relevance is limited.
How serious is the interaction between Isoniazid and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for corticosteroid adverse effects such as hyperglycemia during long-term co-therapy. Monitor liver function as part of routine isoniazid care.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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