Drug interactions
Isoniazid + Rasagiline
Severity: Moderate
Isoniazid and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is an MAO-B inhibitor, and isoniazid has weak MAO inhibiting activity, so combining them may increase the risk of serotonin toxicity or pressor reactions. Clinical data are limited.
What this interaction means in plain words
Isoniazid and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Rasagiline belongs to Central Nervous System.
Why it happens
Additive MAO inhibition from rasagiline and weak MAO inhibition by isoniazid.
What to do
Monitor blood pressure and for serotonin toxicity symptoms, and counsel on tyramine-rich foods. Reassess the need for the combination if hypertension or neuromuscular excitability occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Isoniazid with Rasagiline?
MediHelp rates the interaction as moderate. Isoniazid and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is an MAO-B inhibitor, and isoniazid has weak MAO inhibiting activity, so combining them may increase the risk of serotonin toxicity or pressor reactions. Clinical data are limited.
How serious is the interaction between Isoniazid and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for serotonin toxicity symptoms, and counsel on tyramine-rich foods. Reassess the need for the combination if hypertension or neuromuscular excitability occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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