Drug interactions
Isoniazid + Safinamide
Severity: Moderate
Isoniazid and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide is a reversible MAO-B inhibitor, and isoniazid has weak MAO inhibiting activity. Together they may increase the risk of hypertensive reactions, especially with tyramine-rich foods, and of serotonin toxicity.
What this interaction means in plain words
Isoniazid and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Safinamide belongs to Central Nervous System.
Why it happens
Additive MAO inhibition from safinamide and isoniazid.
What to do
Monitor blood pressure and advise limiting high-tyramine foods such as aged cheeses and cured meats. Watch for serotonin toxicity symptoms and stop one drug if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Isoniazid with Safinamide?
MediHelp rates the interaction as moderate. Isoniazid and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Safinamide is a reversible MAO-B inhibitor, and isoniazid has weak MAO inhibiting activity. Together they may increase the risk of hypertensive reactions, especially with tyramine-rich foods, and of serotonin toxicity.
How serious is the interaction between Isoniazid and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and advise limiting high-tyramine foods such as aged cheeses and cured meats. Watch for serotonin toxicity symptoms and stop one drug if they occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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