Drug interactions
Isoniazid + Trabectedin
Severity: Moderate
Isoniazid and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin is metabolized mainly by CYP3A4, and strong inhibitors markedly increase exposure and toxicity such as hepatotoxicity and myelosuppression. Isoniazid is a weak CYP3A inhibitor, so the effect is expected to be smaller. Because of trabectedin's narrow therapeutic index, caution is still justified.
What this interaction means in plain words
Isoniazid and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Trabectedin belongs to Oncology.
Why it happens
Isoniazid may weakly inhibit CYP3A4, reducing trabectedin clearance, with additive hepatotoxic potential.
What to do
Monitor liver enzymes and blood counts closely during cycles given with isoniazid. Consider an alternative antituberculosis regimen if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Trabectedin
Frequently asked questions
Can I take Isoniazid with Trabectedin?
MediHelp rates the interaction as moderate. Isoniazid and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trabectedin is metabolized mainly by CYP3A4, and strong inhibitors markedly increase exposure and toxicity such as hepatotoxicity and myelosuppression. Isoniazid is a weak CYP3A inhibitor, so the effect is expected to be smaller. Because of trabectedin's narrow therapeutic index, caution is still justified.
How serious is the interaction between Isoniazid and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood counts closely during cycles given with isoniazid. Consider an alternative antituberculosis regimen if feasible.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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