Drug interactions
Carbamazepine + Trabectedin
Severity: Major
Carbamazepine and Trabectedin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may decrease trabectedin exposure and reduce efficacy. Trabectedin is a CYP3A4 substrate and has a narrow therapeutic margin.
What this interaction means in plain words
Carbamazepine and Trabectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Trabectedin belongs to Oncology.
Why it happens
CYP3A4 induction by carbamazepine increases trabectedin metabolism.
What to do
Avoid strong CYP3A4 inducers with trabectedin and use an alternative anticonvulsant. If unavoidable, monitor for reduced response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Trabectedin
Frequently asked questions
Can I take Carbamazepine with Trabectedin?
MediHelp rates the interaction as major. Carbamazepine and Trabectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine may decrease trabectedin exposure and reduce efficacy. Trabectedin is a CYP3A4 substrate and has a narrow therapeutic margin.
How serious is the interaction between Carbamazepine and Trabectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inducers with trabectedin and use an alternative anticonvulsant. If unavoidable, monitor for reduced response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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