Drug interactions
Isoniazid + Triamcinolone
Severity: Minor
Isoniazid and Triamcinolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is not a recognized clinically significant CYP3A4 inhibitor affecting triamcinolone, so a pharmacokinetic interaction is not well established. Isoniazid has weak, variable effects on some CYP enzymes, but there is no reliable evidence of increased corticosteroid exposure.
What this interaction means in plain words
Isoniazid and Triamcinolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoniazid belongs to Anti Bacterial; Triamcinolone belongs to Endocrine.
Why it happens
No well-established mechanism; isoniazid may weakly inhibit CYP3A4 in some patients.
What to do
No dose change is generally needed; monitor for signs of corticosteroid excess if both are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Triamcinolone?
MediHelp rates the interaction as minor. Isoniazid and Triamcinolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is not a recognized clinically significant CYP3A4 inhibitor affecting triamcinolone, so a pharmacokinetic interaction is not well established. Isoniazid has weak, variable effects on some CYP enzymes, but there is no reliable evidence of increased corticosteroid exposure.
How serious is the interaction between Isoniazid and Triamcinolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for signs of corticosteroid excess if both are used long term.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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