Drug interactions
Isoniazid + Vincristine
Severity: Moderate
Isoniazid and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are neurotoxic, and isoniazid may raise vincristine exposure by inhibiting CYP3A4. Together they may increase the risk and severity of peripheral neuropathy.
What this interaction means in plain words
Isoniazid and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Vincristine belongs to Oncology.
Why it happens
Additive peripheral neurotoxicity with possible CYP3A4 inhibition by isoniazid reducing vincristine clearance.
What to do
Assess neuropathy at each cycle, ensure pyridoxine supplementation, and reduce or hold vincristine if neurotoxicity progresses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Isoniazid with Vincristine?
MediHelp rates the interaction as moderate. Isoniazid and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are neurotoxic, and isoniazid may raise vincristine exposure by inhibiting CYP3A4. Together they may increase the risk and severity of peripheral neuropathy.
How serious is the interaction between Isoniazid and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess neuropathy at each cycle, ensure pyridoxine supplementation, and reduce or hold vincristine if neurotoxicity progresses.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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