Drug interactions
Isoniazid + Vinorelbine
Severity: Moderate
Isoniazid and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may modestly increase vinorelbine exposure through CYP3A4 inhibition, and both drugs can cause neuropathy. This may increase neurotoxicity and myelosuppression.
What this interaction means in plain words
Isoniazid and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoniazid belongs to Anti Bacterial; Vinorelbine belongs to Oncology.
Why it happens
Possible CYP3A4 inhibition by isoniazid combined with additive neurotoxicity.
What to do
Monitor neutrophil counts and neuropathy symptoms, give pyridoxine with isoniazid, and adjust vinorelbine dose according to toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Vinorelbine
Frequently asked questions
Can I take Isoniazid with Vinorelbine?
MediHelp rates the interaction as moderate. Isoniazid and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may modestly increase vinorelbine exposure through CYP3A4 inhibition, and both drugs can cause neuropathy. This may increase neurotoxicity and myelosuppression.
How serious is the interaction between Isoniazid and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and neuropathy symptoms, give pyridoxine with isoniazid, and adjust vinorelbine dose according to toxicity.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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