Drug interactions
Isosorbide dinitrate + Nafcillin
Severity: Minor
Isosorbide dinitrate and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4, but isosorbide dinitrate is cleared mainly by non-CYP routes. A meaningful loss of efficacy is unlikely.
What this interaction means in plain words
Isosorbide dinitrate and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin induces CYP3A4, a minor pathway for dinitrate.
What to do
No action beyond awareness. Reassess anginal control if symptoms change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Frequently asked questions
Can I take Isosorbide dinitrate with Nafcillin?
MediHelp rates the interaction as minor. Isosorbide dinitrate and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin induces CYP3A4, but isosorbide dinitrate is cleared mainly by non-CYP routes. A meaningful loss of efficacy is unlikely.
How serious is the interaction between Isosorbide dinitrate and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond awareness. Reassess anginal control if symptoms change.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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