Drug interactions
Isosorbide dinitrate + Rifampin
Severity: Minor
Isosorbide dinitrate and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong CYP3A4 inducer and may reduce levels of some co-administered drugs. Isosorbide dinitrate relies mostly on non-CYP denitration, so any loss of effect is expected to be small, but it cannot be fully excluded.
What this interaction means in plain words
Isosorbide dinitrate and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induces CYP3A4 and other enzymes, which may slightly increase isosorbide dinitrate clearance.
What to do
No empirical dose change is needed. Reassess anginal control during and after rifampin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Frequently asked questions
Can I take Isosorbide dinitrate with Rifampin?
MediHelp rates the interaction as minor. Isosorbide dinitrate and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin is a strong CYP3A4 inducer and may reduce levels of some co-administered drugs. Isosorbide dinitrate relies mostly on non-CYP denitration, so any loss of effect is expected to be small, but it cannot be fully excluded.
How serious is the interaction between Isosorbide dinitrate and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Reassess anginal control during and after rifampin therapy.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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