Drug interactions
Isosorbide mononitrate + Nafcillin
Severity: Minor
Isosorbide mononitrate and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer, but isosorbide mononitrate is cleared mainly by non-CYP routes. A clinically relevant loss of efficacy is unlikely.
What this interaction means in plain words
Isosorbide mononitrate and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin induces CYP3A4, a minor elimination pathway for mononitrate.
What to do
No action is needed beyond awareness. Reassess anginal control if symptoms change during a prolonged nafcillin course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Frequently asked questions
Can I take Isosorbide mononitrate with Nafcillin?
MediHelp rates the interaction as minor. Isosorbide mononitrate and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is a CYP3A4 inducer, but isosorbide mononitrate is cleared mainly by non-CYP routes. A clinically relevant loss of efficacy is unlikely.
How serious is the interaction between Isosorbide mononitrate and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness. Reassess anginal control if symptoms change during a prolonged nafcillin course.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
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