Drug interactions
Isradipine + Ketoconazole
Severity: Moderate
Isradipine and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can increase isradipine concentrations, leading to exaggerated vasodilation with hypotension, flushing, headache and peripheral edema. Dihydropyridine calcium channel blockers are generally sensitive to potent CYP3A4 inhibition.
What this interaction means in plain words
Isradipine and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ketoconazole inhibits CYP3A4-mediated first-pass and systemic metabolism of isradipine.
What to do
Monitor blood pressure and edema when starting or stopping ketoconazole, and reduce the isradipine dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Isradipine with Ketoconazole?
MediHelp rates the interaction as moderate. Isradipine and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole can increase isradipine concentrations, leading to exaggerated vasodilation with hypotension, flushing, headache and peripheral edema. Dihydropyridine calcium channel blockers are generally sensitive to potent CYP3A4 inhibition.
How serious is the interaction between Isradipine and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when starting or stopping ketoconazole, and reduce the isradipine dose if hypotension or adverse effects occur.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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