Drug interactions
Isradipine + Lorlatinib
Severity: Moderate
Isradipine and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine undergoes extensive CYP3A4 metabolism, so lorlatinib may reduce its plasma levels. Blood pressure control or antianginal effect could be diminished.
What this interaction means in plain words
Isradipine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lorlatinib induces CYP3A4, increasing first-pass and systemic clearance of isradipine.
What to do
Monitor blood pressure and heart rate after starting or stopping lorlatinib. Titrate the isradipine dose to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Isradipine with Lorlatinib?
MediHelp rates the interaction as moderate. Isradipine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isradipine undergoes extensive CYP3A4 metabolism, so lorlatinib may reduce its plasma levels. Blood pressure control or antianginal effect could be diminished.
How serious is the interaction between Isradipine and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or stopping lorlatinib. Titrate the isradipine dose to effect.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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