Drug interactions
Isradipine + Nifedipine
Severity: Moderate
Isradipine and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dihydropyridine calcium channel blockers of the same class, so combining them gives duplicate therapy with additive vasodilation. This raises the risk of hypotension, reflex tachycardia, flushing and edema without added benefit.
What this interaction means in plain words
Isradipine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive L-type calcium channel blockade and vasodilation from therapeutic duplication.
What to do
Avoid combining two dihydropyridines; use one agent and add a different antihypertensive class if more control is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isradipine and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nifedipine
Frequently asked questions
Can I take Isradipine with Nifedipine?
MediHelp rates the interaction as moderate. Isradipine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dihydropyridine calcium channel blockers of the same class, so combining them gives duplicate therapy with additive vasodilation. This raises the risk of hypotension, reflex tachycardia, flushing and edema without added benefit.
How serious is the interaction between Isradipine and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines; use one agent and add a different antihypertensive class if more control is needed.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
