Drug interactions
Isradipine + Oxcarbazepine
Severity: Moderate
Isradipine and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can reduce plasma levels of dihydropyridine calcium channel blockers metabolized by CYP3A4. Blood pressure control may be weaker than expected.
What this interaction means in plain words
Isradipine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Oxcarbazepine induces CYP3A4, increasing isradipine first-pass and systemic metabolism.
What to do
Monitor blood pressure and heart rate after starting or stopping oxcarbazepine, and titrate isradipine as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Isradipine with Oxcarbazepine?
MediHelp rates the interaction as moderate. Isradipine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine can reduce plasma levels of dihydropyridine calcium channel blockers metabolized by CYP3A4. Blood pressure control may be weaker than expected.
How serious is the interaction between Isradipine and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or stopping oxcarbazepine, and titrate isradipine as needed.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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