Drug interactions
Isradipine + Quinine
Severity: Minor
Isradipine and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine prolongs the QT interval and has a recognized torsade risk. Isradipine is a dihydropyridine calcium channel blocker with little direct QT effect, so the pharmacodynamic overlap is weak. Quinine may also modestly raise isradipine exposure via CYP3A4, increasing hypotension.
What this interaction means in plain words
Isradipine and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak additive QT effect and minor CYP3A4 inhibition by quinine; the interaction is not firmly established.
What to do
No routine change is needed; monitor blood pressure when starting quinine. Check an ECG if other QT-prolonging drugs or electrolyte disturbances are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Isradipine with Quinine?
MediHelp rates the interaction as minor. Isradipine and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinine prolongs the QT interval and has a recognized torsade risk. Isradipine is a dihydropyridine calcium channel blocker with little direct QT effect, so the pharmacodynamic overlap is weak. Quinine may also modestly raise isradipine exposure via CYP3A4, increasing hypotension.
How serious is the interaction between Isradipine and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood pressure when starting quinine. Check an ECG if other QT-prolonging drugs or electrolyte disturbances are present.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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