Drug interactions
Isradipine + Tadalafil
Severity: Moderate
Isradipine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine and tadalafil both lower blood pressure, so the combination may cause additive hypotension and dizziness.
What this interaction means in plain words
Isradipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from calcium channel blockade and PDE5 inhibition.
What to do
Monitor blood pressure, particularly when starting tadalafil or changing the isradipine dose. Counsel patients on orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Isradipine with Tadalafil?
MediHelp rates the interaction as moderate. Isradipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isradipine and tadalafil both lower blood pressure, so the combination may cause additive hypotension and dizziness.
How serious is the interaction between Isradipine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, particularly when starting tadalafil or changing the isradipine dose. Counsel patients on orthostatic symptoms.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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