Drug interactions
Isradipine + Timolol
Severity: Moderate
Isradipine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining timolol with a dihydropyridine calcium channel blocker gives additive blood pressure lowering. Isradipine has little direct effect on conduction, but hypotension or, occasionally, heart failure worsening can occur in susceptible patients.
What this interaction means in plain words
Isradipine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects: beta-blockade reduces cardiac output while isradipine causes arterial vasodilation.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Titrate doses gradually, especially in patients with left ventricular dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Isradipine with Timolol?
MediHelp rates the interaction as moderate. Isradipine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining timolol with a dihydropyridine calcium channel blocker gives additive blood pressure lowering. Isradipine has little direct effect on conduction, but hypotension or, occasionally, heart failure worsening can occur in susceptible patients.
How serious is the interaction between Isradipine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Titrate doses gradually, especially in patients with left ventricular dysfunction.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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