Drug interactions
Istradefylline + Lansoprazole
Severity: Minor
Istradefylline and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the 40 mg daily dose, istradefylline increases exposure to CYP3A4 substrates, which could modestly raise lansoprazole levels. The clinical consequence is expected to be small given lansoprazole's wide safety margin.
What this interaction means in plain words
Istradefylline and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, reducing lansoprazole metabolism.
What to do
No routine change is needed; monitor for lansoprazole adverse effects when istradefylline 40 mg daily is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Lansoprazole?
MediHelp rates the interaction as minor. Istradefylline and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the 40 mg daily dose, istradefylline increases exposure to CYP3A4 substrates, which could modestly raise lansoprazole levels. The clinical consequence is expected to be small given lansoprazole's wide safety margin.
How serious is the interaction between Istradefylline and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for lansoprazole adverse effects when istradefylline 40 mg daily is used.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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