Drug interactions
Istradefylline + Metformin-sitagliptin
Severity: Minor
Istradefylline and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses can inhibit P-glycoprotein and increase exposure to P-gp substrates such as sitagliptin. Because sitagliptin has a wide safety margin, the effect is usually of limited clinical importance.
What this interaction means in plain words
Istradefylline and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
P-glycoprotein inhibition by istradefylline reduces efflux of sitagliptin and raises its exposure.
What to do
No routine dose change is needed; monitor for adverse effects and glucose response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Istradefylline and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses can inhibit P-glycoprotein and increase exposure to P-gp substrates such as sitagliptin. Because sitagliptin has a wide safety margin, the effect is usually of limited clinical importance.
How serious is the interaction between Istradefylline and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for adverse effects and glucose response.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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