Drug interactions
Istradefylline + Rabeprazole
Severity: Minor
Istradefylline and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits CYP3A4, but rabeprazole is cleared mainly by non-enzymatic reduction, with only a minor CYP3A4 and CYP2C19 contribution. A meaningful rise in rabeprazole exposure is unlikely.
What this interaction means in plain words
Istradefylline and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by istradefylline at 40 mg/day affects a minor pathway of rabeprazole clearance.
What to do
No dose adjustment of rabeprazole is expected to be needed. Monitor for PPI adverse effects if the high istradefylline dose is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Rabeprazole?
MediHelp rates the interaction as minor. Istradefylline and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses inhibits CYP3A4, but rabeprazole is cleared mainly by non-enzymatic reduction, with only a minor CYP3A4 and CYP2C19 contribution. A meaningful rise in rabeprazole exposure is unlikely.
How serious is the interaction between Istradefylline and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment of rabeprazole is expected to be needed. Monitor for PPI adverse effects if the high istradefylline dose is used.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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