Drug interactions
Istradefylline + Tenofovir disoproxil
Severity: Minor
Istradefylline and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline can raise exposure to P-glycoprotein substrates at higher doses. Tenofovir disoproxil is transported by P-gp in the gut, so its absorption and exposure may rise modestly. The clinical significance is likely small but renal safety matters with tenofovir.
What this interaction means in plain words
Istradefylline and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Istradefylline inhibits intestinal P-glycoprotein efflux, potentially increasing tenofovir disoproxil absorption.
What to do
Monitor for tenofovir-related adverse effects and renal function (creatinine clearance, phosphate) during coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Istradefylline and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline can raise exposure to P-glycoprotein substrates at higher doses. Tenofovir disoproxil is transported by P-gp in the gut, so its absorption and exposure may rise modestly. The clinical significance is likely small but renal safety matters with tenofovir.
How serious is the interaction between Istradefylline and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tenofovir-related adverse effects and renal function (creatinine clearance, phosphate) during coadministration.
What other medicines interact with Istradefylline?
MediHelp also lists interactions of Istradefylline with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Istradefylline page.
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