Drug interactions
Ivosidenib + Ketamine
Severity: Minor
Ivosidenib and Ketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer and may lower ketamine concentrations, especially after oral dosing, reducing effect. Clinical significance with titrated intravenous use is likely modest.
What this interaction means in plain words
Ivosidenib and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivosidenib belongs to Oncology; Ketamine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases ketamine metabolism.
What to do
Titrate ketamine to clinical response and expect higher dose needs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Ketamine?
MediHelp rates the interaction as minor. Ivosidenib and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib is a CYP3A4 inducer and may lower ketamine concentrations, especially after oral dosing, reducing effect. Clinical significance with titrated intravenous use is likely modest.
How serious is the interaction between Ivosidenib and Ketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to clinical response and expect higher dose needs.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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