Drug interactions
Ivosidenib + Lansoprazole
Severity: Minor
Ivosidenib and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower concentrations of lansoprazole, which is partly metabolised by this enzyme. Since CYP2C19 is the main pathway and lansoprazole is dose-titratable, the effect is usually small.
What this interaction means in plain words
Ivosidenib and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivosidenib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Ivosidenib induction of CYP3A4 increases lansoprazole clearance.
What to do
No empirical change is needed; watch for reduced acid suppression and increase the PPI dose if symptoms recur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Lansoprazole?
MediHelp rates the interaction as minor. Ivosidenib and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib induces CYP3A4 and may lower concentrations of lansoprazole, which is partly metabolised by this enzyme. Since CYP2C19 is the main pathway and lansoprazole is dose-titratable, the effect is usually small.
How serious is the interaction between Ivosidenib and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical change is needed; watch for reduced acid suppression and increase the PPI dose if symptoms recur.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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