Drug interactions
Ivosidenib + Sildenafil
Severity: Moderate
Ivosidenib and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib has mixed effects on CYP3A4, and its net effect on sildenafil exposure is uncertain. Sildenafil levels might fall or rise, so efficacy or adverse effects could change.
What this interaction means in plain words
Ivosidenib and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Sildenafil belongs to Genitourinary.
Why it happens
Ivosidenib induces CYP3A4 and may also inhibit it, so its net effect on sildenafil metabolism is unpredictable.
What to do
Monitor for changes in sildenafil effect and tolerability, and adjust the dose accordingly. Consider an alternative if the combination is hard to manage.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Sildenafil?
MediHelp rates the interaction as moderate. Ivosidenib and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib has mixed effects on CYP3A4, and its net effect on sildenafil exposure is uncertain. Sildenafil levels might fall or rise, so efficacy or adverse effects could change.
How serious is the interaction between Ivosidenib and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for changes in sildenafil effect and tolerability, and adjust the dose accordingly. Consider an alternative if the combination is hard to manage.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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