Drug interactions
Ivosidenib + Theophylline
Severity: Moderate
Ivosidenib and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4, which could modestly lower theophylline concentrations. Because CYP3A4 is a secondary pathway for theophylline, the effect is likely small, but loss of bronchodilator control is possible.
What this interaction means in plain words
Ivosidenib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Ivosidenib induces CYP3A4, a minor route of theophylline metabolism, increasing its clearance.
What to do
Monitor theophylline serum levels and respiratory symptoms after ivosidenib is started or stopped, and adjust the theophylline dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Theophylline?
MediHelp rates the interaction as moderate. Ivosidenib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4, which could modestly lower theophylline concentrations. Because CYP3A4 is a secondary pathway for theophylline, the effect is likely small, but loss of bronchodilator control is possible.
How serious is the interaction between Ivosidenib and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and respiratory symptoms after ivosidenib is started or stopped, and adjust the theophylline dose as needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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