Drug interactions
Ivosidenib + Ulipristal
Severity: Major
Ivosidenib and Ulipristal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower ulipristal exposure, risking contraceptive failure.
What this interaction means in plain words
Ivosidenib and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ivosidenib induces CYP3A4, increasing ulipristal clearance.
What to do
Avoid ulipristal and use a copper intrauterine device. Advise reliable non-hormonal contraception during ivosidenib therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Ulipristal?
MediHelp rates the interaction as major. Ivosidenib and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib induces CYP3A4 and may lower ulipristal exposure, risking contraceptive failure.
How serious is the interaction between Ivosidenib and Ulipristal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ulipristal and use a copper intrauterine device. Advise reliable non-hormonal contraception during ivosidenib therapy.
What other medicines interact with Ivosidenib?
MediHelp also lists interactions of Ivosidenib with, for example, Alfuzosin, Amiodarone, Amisulpride. The full list is on the Ivosidenib page.
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