Drug interactions
Ivosidenib + Venlafaxine
Severity: Minor
Ivosidenib and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower venlafaxine concentrations. Because CYP3A4 is a minor pathway for venlafaxine, the effect is probably small, and ivosidenib also carries QT risk.
What this interaction means in plain words
Ivosidenib and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivosidenib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by ivosidenib with a small increase in venlafaxine clearance, plus possible additive QT effect.
What to do
Monitor for reduced antidepressant response and check ECG and electrolytes in line with ivosidenib labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Venlafaxine?
MediHelp rates the interaction as minor. Ivosidenib and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib induces CYP3A4 and may lower venlafaxine concentrations. Because CYP3A4 is a minor pathway for venlafaxine, the effect is probably small, and ivosidenib also carries QT risk.
How serious is the interaction between Ivosidenib and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and check ECG and electrolytes in line with ivosidenib labeling.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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