Drug interactions
Ivosidenib + Zolpidem
Severity: Moderate
Ivosidenib and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib may lower zolpidem concentrations, potentially reducing hypnotic efficacy. The risk is loss of effect rather than toxicity.
What this interaction means in plain words
Ivosidenib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by ivosidenib, increasing zolpidem metabolism.
What to do
Monitor for reduced hypnotic effect and consider an alternative insomnia agent if efficacy is lost; avoid empirical high zolpidem doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Zolpidem?
MediHelp rates the interaction as moderate. Ivosidenib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib may lower zolpidem concentrations, potentially reducing hypnotic efficacy. The risk is loss of effect rather than toxicity.
How serious is the interaction between Ivosidenib and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic effect and consider an alternative insomnia agent if efficacy is lost; avoid empirical high zolpidem doses.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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