Drug interactions
Ixabepilone + Oxcarbazepine
Severity: Moderate
Ixabepilone and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce ixabepilone exposure and potentially diminish anticancer efficacy.
What this interaction means in plain words
Ixabepilone and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Oxcarbazepine induces CYP3A4, which metabolizes ixabepilone.
What to do
Prefer a non-inducing anticonvulsant during ixabepilone therapy. If unavoidable, monitor tumor response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Ixabepilone with Oxcarbazepine?
MediHelp rates the interaction as moderate. Ixabepilone and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce ixabepilone exposure and potentially diminish anticancer efficacy.
How serious is the interaction between Ixabepilone and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing anticonvulsant during ixabepilone therapy. If unavoidable, monitor tumor response and toxicity.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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