Drug interactions
Japanese encephalitis virus vaccine + Tocilizumab
Severity: Moderate
Japanese encephalitis virus vaccine and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from tocilizumab may lower the antibody response to Japanese encephalitis vaccine. Inactivated vaccines are safe to give, but protection may be incomplete in travellers to endemic areas.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IL-6 receptor blockade dampens humoral immune responses to vaccination.
What to do
Complete vaccination at least 2 weeks before starting tocilizumab if possible; otherwise consider checking antibody titres after the course for high-risk travel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Tocilizumab?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from tocilizumab may lower the antibody response to Japanese encephalitis vaccine. Inactivated vaccines are safe to give, but protection may be incomplete in travellers to endemic areas.
How serious is the interaction between Japanese encephalitis virus vaccine and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination at least 2 weeks before starting tocilizumab if possible; otherwise consider checking antibody titres after the course for high-risk travel.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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