Drug interactions
Ketamine + Larotrectinib
Severity: Minor
Ketamine and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate that is reported to inhibit CYP3A4 weakly, so ketamine levels may rise slightly. The expected clinical effect is small.
What this interaction means in plain words
Ketamine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketamine belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing ketamine clearance.
What to do
No routine adjustment is needed; titrate ketamine to clinical response and observe for prolonged sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Other interactions of Larotrectinib
Frequently asked questions
Can I take Ketamine with Larotrectinib?
MediHelp rates the interaction as minor. Ketamine and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate that is reported to inhibit CYP3A4 weakly, so ketamine levels may rise slightly. The expected clinical effect is small.
How serious is the interaction between Ketamine and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; titrate ketamine to clinical response and observe for prolonged sedation.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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